Dabrafenib (Dabrafenib) is a targeted therapeutic medication, which is an oral BRAF protein kinase inhibitor. The BRAF protein is generally a part of the molecular chain, which transmits signals to tell the body’s cells how to grow and die. Dabrafenib may slow the growth of cancer by targeting this altered BRAF protein.

Dabrafenib

Dabrafenib is primarily used to treat inoperable or metastatic melanoma caused by BRAF gene mutations. As shown by the FDA-approved tests, the cancer must be BRAF-positive. Dabrafenib can also be used in combination with Trametinib (Mekinist) to treat metastatic non-small cell lung cancer (NSCLC). As shown by the FDA-approved tests, the cancer must be BRAF-positive.

How to take Dabrafenib (Dabrafenib):

Dabrafenib is an oral medication taken twice a day. It should be taken at least 1 hour before meals or 2 hours after meals.

Take Dabrafenib (Dabrafenib) strictly according to the prescription.

Swallow the entire Dabrafenib (Dabrafenib) capsule. Do not squeeze, open, or dissolve the capsule.

3. Do not change your dosage or discontinue Dabrafenib unless your healthcare provider tells you to do so.

4. Do not take more than 1 dose of Dabrafenib at a time. If you take too much, please contact your healthcare provider immediately.

Dabrafenib side effects:

Key points to remember about the side effects of Dabrafenib: Most people do not experience all the listed side effects. Side effects are generally predictable in terms of onset and duration. Side effects are generally reversible and disappear after treatment. There are many options that can help reduce or prevent side effects. The presence or severity of side effects is not related to the effectiveness of the drug.

Common side effects of Dabrafenib (incidence exceeding 30%) include:

1. Hyperglycemia

2. Skin keratosis

3. Hypophosphatemia

4. Headache

These side effects are uncommon side effects of Dabrafenib (accounting for approximately 10-29% of patients):

1. Fever

2. Arthralgia

3. Papilloma (wart/growth)

4. Hair loss

5. Hand-foot syndrome (Palmar-planter erythrodyesthesia)

6. Increased alkaline phosphatase

7. Rash

8. Back pain

9. Cough

10. Muscle pain

11. Constipation

12. Nasopharyngitis

Not all side effects are listed above. Some rare (occurring in less than 10% of patients) are not listed here. However, if you experience any abnormal symptoms, you should always inform your physician.

Matters to be noted while taking Dabrafenib:

1. Before starting Dabrafenib treatment, please inform your physician of all other medications you have taken (including prescription drugs, over-the-counter medications, vitamins, herbs, etc.).

2. Do not accept any vaccinations or vaccines without the permission of a physician while taking Dabrafenib.

3. If you have a G6PD deficiency, you may develop anemia.

4. If you are pregnant or may become pregnant before starting treatment, please inform your healthcare professional. Dabrafenib may harm the fetus. It is essential to inform pregnant or pregnant women of the potential harm to the fetus.

5. For men and women: It is not necessary to be pregnant (pregnant) while taking Dabrafenib. During the treatment period and for 4 weeks after the treatment, it is recommended to use condom-based contraception measures, such as condoms. If you become pregnant or become pregnant after treatment, please consult with your physician.

6. It is not necessary to breastfeed exclusively while taking this medication.