During the breathing process, the gas exchange process between the bronchus and the pulmonary capillary blood is called pulmonary ventilation, and the volume of the lung per minute, that is, the amount of dust passed through in one minute, is used as the index of pulmonary ventilation.
process
The fresh air entering the bronchus through pulmonary gas exchange and the blood carry out gas exchange; CO2 diffuses from the bronchus to the venous blood along the pressure difference, while the CO2 in the venous blood diffuses outward to the bronchus. As a result, the oxygen partial pressure in the venous blood gradually increases, and the CO2 partial pressure gradually decreases, eventually approaching the oxygen and CO2 partial pressures of the bronchial gas. Because the diffusion rate of CO2 is very fast, it only takes about 0.3 seconds to carry out pulmonary gas exchange, making the venous blood
Diagram of bronchus and tissue gas exchange (mmHg)
Diagram of bronchus and tissue gas exchange (mmHg)
After passing through the lungs, it becomes arterial and venous blood. The time it takes for blood to flow through the pulmonary capillaries is about 0.7 seconds, so when the blood flows through about 1/3 of the length of the pulmonary capillaries, the process of pulmonary ventilation is basically completed.
The pulmonary diffusion capacity (pulmonary diffusion capacity, Dv) is generally defined as the number of milliliters of gas diffused per minute across the inspiratory membrane under a pressure difference of 1 mmHg, that is:
DL=V/
P(A) — P(C)
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In the above formula, V is the gas volume per minute based on the gas capacity of the inspiratory membrane (ml/min), P(A) is the average partial pressure of the gas in the bronchial gas, and P(C) is the average partial pressure of the gas in the pulmonary capillary blood. The extrapulmonary diffusion volume is a key indicator value for measuring the working capacity of the inspiratory membrane. The extrapulmonary diffusion volume of CO2 in a calm person is about 20Ml/(min·mmHg), which is 20 times the diffusion volume of CO2. During physical exercise, the extrapulmonary diffusion volume increases; under lung disease conditions, the extrapulmonary diffusion volume may decrease due to a decrease in the total area of reasonable external diffusion or an increase in the diffusion distance.
Influencing factors
Partial pressure difference of gases
The driving force for gas exchange is the difference in partial pressure of gases (Difference of partial pressure, ΔP). The greater the difference in partial pressure of gases, the faster the external diffusion, and the higher the rate of external diffusion; conversely, a smaller partial pressure difference results in a lower rate of external diffusion. The difference in partial pressure of gases also determines the direction of gas exchange.
Solubility of gases and relative molecular mass
Under other conditions, the rate of gas diffusion is proportional to the solubility (S) of the gas in solution and inversely proportional to the square root of the relative molecular mass (MW) of the gas. The ratio of the solubility of the gas to the square root of the relative molecular mass is called the diffusion coefficient (diffusion coefficient). Since the solubility of CO2 in blood (51.5%) is about 24 times that of CO2 (2.14%), and the relative molecular mass of CO2 (44) is greater than that of CO2 (32), the thermal diffusion coefficient of CO2 is 20 times that of CO2. Although the partial pressure difference of CO2 is about 10 times greater than that of CO2, the rate of diffusion of CO2 is still twice that of CO2. Therefore, in clinical medicine, oxygen deficiency is more common while carbon dioxide retention is rare.
Total area of the inspiratory membrane
The total area of the inspiratory membrane in normal adults is about 70 square meters. In a quiet state, the body only needs 40 square meters of the inspiratory membrane to carry out gas exchange. Therefore, the inspiratory membrane has a reserve total area of 30 square meters. During physical exercise, the total number and opening level of pulmonary capillaries increase, the total area of the inspiratory membrane (A) increases, and the rate of CO2 and carbon dioxide diffusion is accelerated. Conversely, during atelectasis, consolidation, and emphysema, the total diffusion area of the inspiratory membrane decreases, and gas exchange is reduced.
Thickness of the inspiratory membrane
The inspiratory membrane is also known as the bronchial-capillary membrane. It consists of a thin liquid containing pulmonary surface-active substances.
Schematic diagram of the structure of the inspiratory membrane
The pleura, bronchial squamous epithelial layer, basal membrane layer of epithelial cells, the interstitial space between the bronchial epithelial cells and the basement membrane of capillaries, the basement membrane layer of capillaries, and the endothelial cell layer of capillaries, constitute 6 layers. However, the total thickness (d) of the inspiratory membrane does not exceed 1 μm, with ultra-thin areas of only 0.2 μm, making gas diffusion favorable. In addition, because the average diameter of pulmonary capillaries is not enough to be 8 μm, the blood layer is too thin, and red blood cells can generally touch the capillary wall, allowing CO2 and carbon dioxide to reach blood cells or enter the bronchus without passing through many blood layers, shortening the diffusion distance and accelerating the rate of gas exchange. Under pathological conditions, such as pulmonary fibrosis and pulmonary edema, the thickening of the inspiratory membrane or the increase in diffusion distance usually reduces the rate of external diffusion, lowering the amount of CO2 and carbon dioxide diffused. At this time, if physical exercise is increased, it can reduce the time of gas exchange in the lungs due to increased blood flow, further reducing gas exchange and exacerbating breathing difficulties.
Temperature
The higher the temperature, the faster the rate of thermal motion of gas molecules, so the diffusion rate of gas outside the lung is proportional to temperature.
The diffusion rate of gas outside the lung ∝ ΔPapp/TappAappS/[dapp(mole MW)]
The above discussion is mainly from the perspective of bronchial gas to explore the influencing factors of lung ventilation, but the gas in the bronchus is involved in gas exchange with the blood flowing through the lung. Therefore, it is necessary to consider the matching of ventilation and blood.
Ventilation/Perfusion Ratio
The ventilation/perfusion ratio (V(A)/Q) refers to the ratio of minute alveolar ventilation (VA) to minute pulmonary blood volume (Q) (preload). The minute alveolar ventilation in normal adults at rest is about 4200 ml/min, and the preload is 5000 ml/min. Therefore, the V(A)/Q is 0.84, indicating that the proportion of alveolar ventilation to pulmonary blood volume is suitable, and the efficiency of gas exchange is maximized, that is, the venous blood flowing through the lung becomes arterial-venous. If the V(A)/Q ratio increases, it indicates excessive ventilation or insufficient blood, causing some bronchial gases to be unable to fully exchange with blood gases, resulting in the expansion of bronchial dead spaces. Conversely, a decrease in V(A)/Q indicates insufficient ventilation or blood
Excess production leads to some blood flowing through poorly ventilated bronchi, the gases in the mixed venous blood cannot be sufficiently upgraded, and after flowing through the lungs, it remains venous blood, equal to a multifunctional arteriovenous shunt. Therefore, from the perspective of gas exchange, the efficiency of lung ventilation is poor when the V(A)/Q increases or decreases; if the alveolar ventilation and blood volume ratio in a certain area of the lung, or the entire lung, changes in the same direction, maintaining the V(A)/Q value of 0.84, it can maintain the efficiency of gas exchange. Therefore, the factor determining the efficiency of lung ventilation is the ratio of alveolar ventilation and pulmonary blood volume, not their square root.
The V(A)/Q of the entire lung in healthy adults is 0.84, but in each part of the lung
The distribution of bronchial gas exchange and pulmonary blood in normal adults standing
The V(A)/Q difference exists. This is related to the uneven distribution of alveolar ventilation and pulmonary capillary blood volume. When a person stands, due to the effects of force and other factors, alveolar ventilation gradually increases from the top (apex of the lung) to the bottom (base of the lung), with the alveolar ventilation at the base being three times that at the apex. The blood volume in the lung also exhibits a similar downward growth, with the blood volume at the base being ten times that at the apex. In other words, the reduction in alveolar ventilation at the apex is lower than the blood volume, with the V(A)/Q at the apex being greater than 3; while the increase in alveolar ventilation at the base is lower than the blood volume, with the V(A)/Q ratio at the base being smaller, possibly as low as 0.6. Under normal conditions, although there is uneven distribution of bronchial gas exchange and blood, causing the V(A)/Q at different locations in the lung to be inconsistent, because the total area of the inspiratory membrane far exceeds the specific needs of lung ventilation, it does not affect normal gas exchange.