Busulfan tablets are used to treat Hodgkin’s disease, various non-Hodgkin’s lymphomas, chronic reticulocytic leukemia, Waldenstrom’s macroglobulinemia, advanced uterine and ovarian adenocarcinoma, and also have a significant effect on some breast cancer patients. This product is a deep brown film-coated, circular biconvex tablet, with ‘GX EG3’ on one side and ‘L’ on the other.

One, Pharmacological Value:

Busulfan is a lipid nitrogen mustard compound and is an alkylating agent with a dual action. It produces alkylating effects by generating an ethyleneimine functional group that causes cross-linking in the two helical strands of DNA, thereby destroying DNA replication.

Two, Scope of Application

Hodgkin’s disease, various non-Hodgkin’s lymphomas, chronic reticulocytic leukemia, Waldenstrom’s macroglobulinemia, advanced uterine and ovarian adenocarcinoma. This product also has a significant effect on some breast cancer patients.

Three, Common Questions

Safety Operation:

Persons handling the tablets should follow the operational guidelines for cytotoxic drugs.

The film-coated tablets of this product are harmless when touched. However, the tablets of this product are indispensable.

Medication Monitoring

Due to the potential for unavoidable bone marrow damage, blood cell counts should be closely monitored during treatment.

The therapeutic dose of this product only inhibits reticulocytes, has little effect on monocytes, platelets, and blood cells. When monocytes begin to decrease, it is not necessary to discontinue the drug, but it must be noted that monocytes may still decrease for up to 10 days or even longer after discontinuation.

Patients who have recently undergone tumor radiotherapy or other cytotoxic drug treatment are not suitable for this product. When there is bone marrow reticulocyte infiltration or hyperplasia, the daily dose should not exceed 0.1mg/kg body weight.

Children and adolescents with nephrotic syndrome, patients with intermittent high-dose busulfan therapy, and patients with a history of epilepsy should strictly monitor their medication status after taking the drug, as the risk of epilepsy increases. As with all potential antiepileptic drugs, extra caution should be exercised when this product is used in patients with a history of epilepsy, patients with head trauma, or patients using other potential antiepileptic drugs.