From: https://www.diseasewiki.com
Why is curcumin not for sale
Curcumin is a component obtained from the underground stems of some green plants in the Zingiberaceae and Araceae families, among which turmeric contains about 3%~6%, which is a very rare diketone pigment in the biological world. It is a type of two-ring lactone compound of acidic polyphenols, with an unsaturated fatty acid chain and a lipophilic functional group. It is generally used as a food additive and an acid-base indicator, and also has medicinal values such as anti-infection and antioxidant. Biologists have explored and found that curcumin is beneficial for treating drug-resistant tuberculosis.
Originally, curcumin has the following functions and effects:
1. Anti-inflammatory, most of the diseases we get are caused by inflammation, and it is relatively difficult to treat when the body organs appear inflammation. Therefore, in daily life, we can eat some substances containing curcumin, which can resist the inflammatory cells in our body and have anti-inflammatory effects.
2. Protecting the central nervous system of the human brain, according to research data reports, curcumin can promote the growth of brain neuron cells, which has a great assisting effect on preventing and reducing the brain’s basic conditions.
3. Alleviating the risk of heart disease, curcumin has certain assisting effects on promoting the circulation of heart blood, and it can also adjust our blood pressure, which is also a benefit for those who are not very good with cardiovascular diseases.
4. Because curcumin has certain anti-inflammatory effects, it has a good therapeutic effect in treating and alleviating the pain caused by rheumatic diseases.
5. Women are particularly fond of curcumin health products, which are indispensable due to their excellent antioxidant effects, which can slow down the rapid aging of our skin and improve its smoothness and elasticity!
In practical application, it is found that curcumin also has certain shortcomings, such as poor solubility, poor reliability, and low digestibility, which is easily converted into glucuronide and sulfonic acid in the gastrointestinal tract, with a fast metabolism and a short half-life of the drug. The existence of these problems has caused its low dissolution rate, limiting its application in the food and drug industry. For example, in human experiments, it can only be detected when the oral dose reaches 10~12g, and 10mg/kg of curcumin is injected intravenously into the white rat.
The higher concentration of blood cells is only 0.36μg/mL; 15 minutes after oral administration of 1.0g/kg of curcumin, the concentration in the blood of the white rat is only 0.13μg/mL, and 1 hour later, the highest concentration reaches 0.22μg/mL, and it is not detected in the blood after 6 hours. When the white rat is orally administered with curcumin, only a small amount is detected in the blood, liver, and kidney functions, 90% is stored in the stomach and colon, and only 1% remains after 24 hours. After intraperitoneal injection of 0.1g/kg of curcumin, the detection 1 hour later finds that the distribution of curcumin in human organs is very different, the most in the gastrointestinal tract (117μg/g), followed by kidney function, blood, and liver, and very low in the human brain (0.4μg/g).