Apolipoprotein E (apolipoprotein E, ApoE) is a polymorphic protein that participates in the transformation and metabolism of proteins, and its genes can regulate many biological functions, and is related to many ophthalmic diseases. The study of ApoE and genetic polymorphism is one of the current hotspots in medical clinical research, and the discussion of their relationships has significant clinical value for the prevention, diagnosis, and treatment of eye diseases. So, what is the harm of high apolipoprotein E?

Harm of high apolipoprotein E

The main harm of high apolipoprotein E is that it may cause hypertension, coronary heart disease, and cerebrovascular diseases. Modern scientific research shows that high apolipoprotein E can have a significant impact on the human body, such as causing hypertension, increasing the risk of coronary heart disease, and the incidence of cerebrovascular diseases. The fundamental reason lies in the fact that apolipoprotein E can cause changes in the vascular endothelium, thereby causing atherosclerosis in the blood vessels. Research has shown that the vast majority of patients with atherosclerosis have a high level of apolipoprotein E. Therefore, for patients with high apolipoprotein E, it is necessary to pay attention and properly handle or treat them, such as doing more physical exercise and taking medication when necessary.

Physiological function of apolipoprotein E

It is the ligand of LDL protein kinase and also the ligand of the liver CM remnant protein kinase, and it is closely related to protein metabolism; ApoE has polymorphism, and polymorphism is closely related to the individual’s blood glucose level and the development of atherosclerosis of the aorta; it participates in the activation of enzymes that hydrolyze fats, and it is involved in hormone regulation and the regeneration of nervous tissue.

Human ApoE is primarily generated in the liver and brain tissue, and it also has the ability to be produced in other tissues containing mononuclear cells (including macrophages). The kidney, uterus, and ovarian granulosa cells in humans can also produce ApoE. The total mRNA expression of ApoE in the brain is one-third of that in the liver, with astrocytes being the key site of production. The function of ApoE converted in the brain may be to distribute long-chain fatty acids within somatic cells, thereby maintaining cholesterol balance in the brain’s natural environment. High concentrations of ApoE are found in brain tumors, suggesting that it may serve as a marker for glioblastoma multiforme.