Mediterranean anemia is a very serious disease. It is a genetic disease with no good treatment method, and only attention should be paid to avoid the birth of moderate to severe Mediterranean anemia patients during the production process. In this case, thalassemia gene detection is required, and this article will introduce the thalassemia gene detection report form.

To determine Mediterranean anemia, a routine blood test must be performed first. If there are abnormalities, a Mediterranean anemia test should be conducted, including hemoglobin electrophoresis, polypeptide chain detection, and thalassemia gene analysis, etc., to clarify the diagnosis of Mediterranean anemia. The interpretation of the results of each item is as follows:

1. Routine Blood Test

Observing the average red blood cell volume (MCV) and the content of red blood cell hemoglobin (MCH), the average red blood cell volume of carriers of various types of thalassemia genes decreases, but it may be normal. Severe, moderate, and mild anemia can reduce hemoglobin (Hb). This will only indicate the risk of thalassemia, but cannot be used as a standard for diagnosis.

2. Hemoglobin Electrophoresis

This detection method can be used to check for abnormal Hb and can make a clear diagnosis for severe and moderate thalassemia. The increase of HbA2 in mild thalassemia is the most important diagnostic basis; when iron deficiency anemia occurs, HbA2 often decreases, which can be distinguished from mild beta thalassemia.

3. Polypeptide Chain Detection

The diagnosis of mild alpha thalassemia is mainly applied in clinical practice. If the polypeptide chain is positive, it can be diagnosed as mild alpha thalassemia clearly.

4. Mediterranean Anemia Gene Analysis

Genetic analysis methods can replace all the above tests, but due to the high requirements for instruments and equipment, laboratories, and technicians, it is difficult for general hospitals to carry out them, and the detection cost is high.

Both partners are mild Mediterranean anemia patients and need to undergo careful prenatal diagnosis; if the results show normal or mild anemia, the impact on the fetus is not significant, and it can be safely delivered; if severe, timely induced labor should be performed to avoid harm to the pregnant woman’s physical and mental health.

This article provides a detailed introduction to the Mediterranean anemia gene detection report form. Both partners carry the Mediterranean anemia gene and should be particularly cautious during childbirth. To avoid the birth of poor children, it is necessary to actively conduct gene detection for Mediterranean anemia after or before pregnancy.