Platelet antigen screening is to ensure a higher safety factor for the entire intravenous injection process of the patient, thereby ensuring the personal safety of the patient to a greater extent. If not screened and injected intravenously immediately, inappropriate platelets may be introduced into the patient’s body, which may seriously delay the patient’s condition. So, what does it mean when the platelet antigen screening is negative, and what applications does it have in clinical medicine?

What does it mean when the platelet antigen screening is negative?

Negative platelet antigen screening means that there are no known antigens corresponding to the antigens in the blood cells to be tested, which can be transfused and will not cause damage to the body.

Clinical application of platelet antigen screening

1.Prevention of non-hemolytic reactions during red blood cell transfusion: The fever response in patients with platelet antibodies after transfusion is significantly higher than in those who are negative. After the intervention strategy for platelet antibodies is adopted, the non-hemolytic fever response is significantly reduced, greatly improving the safety of transfusion.

2.Prevention of platelet transfusion failure: Platelet antibodies are the most important cause of immune disease platelet transfusion failure. Testing platelet antigens is crucial for improving the efficiency of platelet treatment and ensuring the safety of intravenous injection.

3.Most thrombotic diseases can be detected with increased platelet reactivity. P-selectin is a sensitive indicator of platelet activity, while platelet aggregation measurement is relatively simple. Recent research also shows that platelet activity indicators are not only meaningful in reflecting platelet activity but also have prognostic significance for some diseases.

For the cautious consideration of medicine, it is necessary to carry out platelet antigen screening for patients receiving intravenous injections. This test can very well evaluate the various risks of intravenous injection, maximize the benefits of the patients, prevent the occurrence of various risks, and avoid irreparable damage. The above is a detailed introduction to what it means when the platelet antigen screening is negative.

Significance and standard values of platelet antibody detection

1.As one of the diagnostic indicators for refractory thrombocytopenic purpura (ITP), more than 90% of ITP patients show an increase in PAIgG. If PAIgM, PAIgA, and PAC are measured in addition, the detection rate reaches 100%. However, positive reactions are also present in diseases such as SLE and other autoimmune diseases. Some people believe that the level of PAIg increases is inversely proportional to the number of platelets and the survival time of platelets.

2.As an indicator for the efficacy of observation, ITP patients whose PAIgG decreases after adrenocorticotropic hormone treatment show an increase in PAIgG in patients who have recurred.

3.As an indicator for prognosis, ITP patients whose PAIgG decreases after treatment and have not recurred have a good prognosis, whereas the prognosis is poor in the opposite case.

4.As an indicator for the scope of splenectomy, patients with ITP whose PAIgG does not decrease after adrenocorticotropic hormone treatment are candidates for splenectomy.

5.As an indicator for predicting the platelet status of the fetus, if the level of platelet antigen in the blood cells of pregnant women with ITP increases, this antigen can enter the fetal blood circulation through the embryo, causing a decrease in fetal platelets.

Platelet-relatedAntigen

Production reference category vaccine 1.PAIgG0～78.8ng/10^7PLT (Radioimmunoassay).

2.PAIgA0～2ng/10^7PLT (Radioimmunoassay).

3.PAIgM0～7ng/10^7PLT (Radioimmunoassay).

4.PAC330～129ng/10^7PLT (Radioimmunoassay).