Cervical cancer is the only gynecological malignant tumor with a clear etiology, associated with persistent infection of high-risk human papillomavirus (HPV). HPV is a double-stranded DNA virus with a spherical shell, with a diameter of 55nm, mainly infecting the epithelium of the skin and mucous membranes, causing various lesions. More than 200 types of HPV have been identified so far, at least 30 of which are related to mucosal infections of the reproductive tract. 80% of women can be infected with HPV in their lifetime, which is usually cleared naturally within 8-10 months, only a small number (5%) of women present a persistent infection state.
Other high-risk factors associated with cervical cancer include:
1. Sexual behavior: Early onset of sexual life, multiple sexual partners;
2. Menstrual and childbirth factors: Poor menstrual hygiene, prolonged menstruation, early marriage, early childbirth, multiple births, etc.;
3. Long-term stimulation of the cervix caused by sexually transmitted diseases;
4. Smoking: Nicotine intake reduces the body's immunity, affects the clearance of HPV infection, and increases the risk of cervical cancer, especially squamous cell carcinoma;
5. Long-term use of oral contraceptives: The risk of cervical cancer, especially adenocarcinoma, increases twice after taking oral contraceptives for more than 8 years;
6. Immune deficiency and suppression: HIV infection leads to immune deficiency, and long-term use of immunosuppressive drugs after organ transplantation can increase the incidence of cervical cancer;
7. Other viral infections: The association between herpes virus type II (HSV-II) and the etiology of cervical cancer cannot be excluded.